Which condition would NOT typically cause elevated serum amylase levels?

Peptic ulcer disease typically does not lead to elevated serum amylase levels because it primarily affects the gastrointestinal tract and does not directly involve the pancreas. Serum amylase is an enzyme primarily produced by the pancreas, with its levels rising significantly in conditions that cause pancreatic inflammation or damage.

In contrast, acute pancreatitis is characterized by inflammation of the pancreas, leading to elevated serum amylase. Cholecystitis, while primarily a gallbladder issue, can also cause some rise in amylase due to irritation of the nearby pancreas or shared biliary pathways. Similarly, pancreatic tumors may obstruct the pancreatic duct or cause inflammation, resulting in increased serum amylase levels. Therefore, peptic ulcer disease, which primarily involves erosion of the stomach or duodenal lining without directly impacting pancreatic function, would not be associated with elevated serum amylase.